Lab of Wolfgang Liedtke MD. PhD.

understanding sensory transduction and pain


Wolfgang Liedtke (editor).TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton, FL : CRC Press, 2006.

Wolfgang Liedtke. TRPV Ion Channels and Sensory Transduction of Osmotic and Mechanical Stimuli in Mammals. Chapter 5 in Sensing with Ion Channels (Boris Martinac (editor)). New York, NY : Springer, 2008.

Liedtke W.  A Classic Innate Behavior, Sodium Appetite, Is Driven by Hypothalamic Gene-Regulatory Programs Previously Linked to Addiction and Reward. Chapter 12 in: Neurobiology of Body Fluid Homeostasis: Transduction and Integration. De Luca LA, Menani JV, Johnson AK, editors. Boca Raton (FL): CRC Press; 2014.



Lindy AS, Parekh PK, Zhu R, Kanju P, Chintapalli SV, Tsvilovskyy V, Patterson RL, Anishkin A, van Rossum DB, Liedtke WB.  TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour. Nat Commun. 2014 Sep 2;5:4734

Chen Y, Kanju P, Fang Q, Lee SH, Parekh PK, Lee W, Moore C, Brenner D, Gereau RW 4th, Wang F, Liedtke W. TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. Pain. 2014 Oct 1. pii: S0304-3959 (14) 00456-4


Liedtke W, Zhang JY, Hall RP 3rd, Steinhoff M.  Keratinocyte growth regulation TRP-ed up over downregulated TRPV4?  J Invest Dermatol. 2014 Sep;134(9):2310-2

Leddy HA, McNulty AL, Lee SH, Rothfusz NE, Gloss B, Kirby ML, Hutson MR, Cohn DH, Guilak F, Liedtke W.  Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. FASEB J. 2014 Jun;28(6):2525-2537.

Yeo M, Patisaul H, Liedtke W.  Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity.  Epigenetics. 2013 Nov;8(11):1128-32.

Xia Y, Fu Z, Hu J, Huang C, Paudel O, Cai S, Liedtke W, Sham JS.  TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension Am J Physiol Cell Physiol. 2013 Oct 1;305(7):C704-15.

Fariss MW, Gilmour MI, Reilly CA, Liedtke W, Ghio AJ.  Emerging mechanistic targets in lung injury induced by combustion-generated particles. Toxicol Sci. 2013 Apr;132(2):253-67

Moore C, Cevikbas F, Pasolli HA, Chen Y, Kong W, Kempkes C, Parekh P, Lee SH, Kontchou NA, Ye I, Jokerst NM, Fuchs E, Steinhoff M, Liedtke WB.  UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.PNAS 2013. 110(34):E3225-34.

Chen Y, Williams SH, McNulty AL, Hong JH, Lee SH, Rothfusz NE, Parekh PK, Moore C, Gereau RW 4th, Taylor AB, Wang F, Guilak F, Liedtke W. Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. Pain. 2013 154(8):1295-304.

Kathryn Dunn,. David C. Hill-Eubanks, Wolfgang B. Liedtke and Mark Nelson. TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. PNAS 2013. 110(15): 6157-62

Michele Yeo, Ken Berglund, Michael Hanna, Junjie U. Guo, Jaya Kittur, Maria D. Torres, Joel Abramowitz, Jorge Busciglio, Yuan Gao, Lutz Birnbaumer, and Wolfgang B. Liedtke.  Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. PNAS 2013 ;110(11) : 4315-20

Lee W Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J, Beicker KN, Coles J, Zauscher S, Grandl J, Sachs F, Guilak F, Liedtke WB. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47)