Lab of Wolfgang Liedtke MD. PhD.

understanding sensory transduction and pain

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TRPV4 mRNA expression in the CNS and functional profile
TRPV4 mRNA expression in the CNS and functional profile
TRPV4 gene expression in osm-9 worms
TRPV4 gene expression in osm-9 worms
Hydromineral homeostasis controlled by the CNS
Hydromineral homeostasis controlled by the CNS
Proposed model of DEP-mediated increased expression of MMP-1 by human bronchial epithelia
Proposed model of DEP-mediated increased expression of MMP-1 by human bronchial epithelia
c-FOS immediate early gene protein expression in circumventricular organ VOLT of trpv4-/- mice and w.t. littermates (30’ after 0.5M NaCl i.p.): apparent reduction in number of immunoreactive cells
c-FOS immediate early gene protein expression in circumventricular organ VOLT of trpv4-/- mice and w.t. littermates (30’ after 0.5M NaCl i.p.): apparent reduction in number of immunoreactive cells
Transduction of noxious (painful) stimuli via skin, sensory neuron in the dorsal root ganglion (or trigeminal ganglion), relayed in the spinal cord dorsal horn, ascending, via the spinal cord white matter to the thalamus and cortex.
Transduction of noxious (painful) stimuli via skin, sensory neuron in the dorsal root ganglion (or trigeminal ganglion), relayed in the spinal cord dorsal horn, ascending, via the spinal cord white matter to the thalamus and cortex.
Schematic rendering of a TRP (transient receptor potential) ion channel, featuring a similar build as voltage gated potassium channels, whose structure has been elucidated.
Schematic rendering of a TRP (transient receptor potential) ion channel, featuring a similar build as voltage gated potassium channels, whose structure has been elucidated.
The mouse is a main model organism in the Liedtke-lab; we generate gene-targeted and random-integration transgenic lines of mice as scientific tools.
The mouse is a main model organism in the Liedtke-lab; we generate gene-targeted and random-integration transgenic lines of mice as scientific tools.
Schematic rendering of a novel gene-regulatory mechanism of the major cortical isoform of the neuronal chloride transporter, Kcc2, which is the only outward transporter of neuronal chloride molecules.
Schematic rendering of a novel gene-regulatory mechanism of the major cortical isoform of the neuronal chloride transporter, Kcc2, which is the only outward transporter of neuronal chloride molecules.

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