Lab of Wolfgang Liedtke, MD PhD
The Liedtke Lab is part of the Duke University Center for Translational Neuroscience, which is based in the Division of Neurology (Department of Medicine) and the Department of Neurobiology. We aim to deconstruct sensing mechanisms at the molecular, cellular, organ/systems and organismal level. Specifically, our interest is focused on osmotic and mechanical stimuli as highly relevant sensory cues. The sensory system most pertinent for our mission is the nociceptive system of the nervous system, which is necessary to evoke pain in conscious animals including humans, yet directs aversive behavior in virtually all animals that have a nervous system. Because of the relevance for pain and nociception, besides tonicity and mechanical stimuli, pathophysiologically relevant modulatory co-stimuli such as inflammatory mediators are also being considered. Finally, neural transmission mechanisms of such stimuli are also being explored.
Back row (left to right) : Whasil, Ken, Carlene, JiHee, Yiding, Patrick, Michele, Wolfgang
Front row (left to right) : Vandana, Lily, Sukhee, Jenny, Yong
Welcome
Research in the news:
BPA effects in developing neurons :
Interviews on CBS Radio and NPR-WUNC
Interview with Mary Gore, Sr. Science Writer, Duke News and Communications
Neurons Mature Rapidly at Birth
Diesel Emission Particles and TRPV4 activation
Salt Appetite shares Drug Addiction Pathway
Awards :
Wolfgang Liedtke won the Collaborative Innovator Award of the Duke IGSP to study genome-wide analysis of regulated genes in the mammalian brain in instinctive cravings (2012)
Wolfgang Liedtke, together with Angel Peterchev of the Department of Psychiatry, won a DIBS incubator award "Characterization, Mechanisms, and Modeling of Static Magnetic Field Effects on Neuronal Excitability" (2012)
Wolfgang Liedtke, together with Achelios Therapeutics of Chapel Hill, NC, won a Collaborative Funding Grant of the North Carolina Biotech Center to study translational-medical mechanisms of pain, in particular trigeminal pain (2012).
Wolfgang Liedtke, together with Fan Wang of Duke Cell Biology, won a Duke Institute for Brain Sciences (DIBS) Incubator Award entitled "Transsynaptic labeling and functional characterization of sensorimotor circuits in the mouse trigeminal system" in 2011
Wolfgang Liedtke won the Ruth K Broad Foundation Duke Neuroscience Faculty Scholar Award in 2011
Lily Pham and Jenny Ngo each won a highly selective Duke Undergraduate Neuroscience Fellowship in 2010
Carlene Moore won the best poster award (post-doc category) at the 2010 Neurobiology Department retreat
Nelly Kontchou holds a prestigious Reginaldo Howard Scholarship from Duke University since 2009
Amanda Lindy (alumnus) won an award for her poster "Amino Acids Adjacent to the Pore Helix of OSM-9, a C. elegans TRPV Channel, Contribute to Calcium Permeation of the Predicted Calcium Selectivity Filter" at the 2009 Duke Graduate Student Symposium
Sarah Hochendoner (alumnus) won a 2009 Duke Trinity College Research Forum in Neuroscience Award for her proposal " Link between brain reward pathways and CNS-mediated sodium appetite: regulation of DARPP-32 in response to induced sodium deficiency"
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