Lab of Wolfgang Liedtke MD. PhD.

understanding sensory transduction and pain

The Liedtke-Lab is housed in the Duke University Dept of Neurology. Dr Wolfgang Liedtke (PI) is also affiliated with the Depts of Neurobiology and Anesthesiology. In addition, he was the first hire in the Duke Center for Translational Neuroscience.

The direction of the experimental agenda of the Liedtke Lab is in keeping with Dr Liedtke's clinical aim, that is provision of care for patients suffering from challenging-to-treat head-face-neck pain (trigeminal pain and other cranial nerve pain disorders), and for therapy-refractory pain in general.

We aim to deconstruct sensing mechanisms at the molecular, cellular, organ/systems and organismal level. Specifically, our interest is focused on osmotic and mechanical stimuli as highly relevant sensory cues.

The sensory system most pertinent for our mission is the nociceptive system, which is necessary to evoke pain in conscious animals including humans, yet directs aversive behavior in virtually all animals that have a nervous system.  Because of the relevance for pain and nociception, besides tonicity and mechanical stimuli, pathophysiologically relevant modulatory co-stimuli such as inflammatory mediators are also being considered. Finally, neural transmission mechanisms of such stimuli are also being explored.

TRPV4 activation results in intracellular calcium increase and increase in pERK

Copyright @WLiedtke 2015